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This distinction is relevant when considering mitophagy-oriented strategies, because beneficial effects observed after suppression of downstream inflammatory mediators do not by themselves establish that direct augmentation of mitophagy in PACs would remain advantageous under all pathological conditions

While the studies included in this review were conducted under the NAFLD classification, the transition to MASLD provides a more precise framework for stratifying and managing patients with coexisting metabolic disorders [117]

Effects in active malignancy are not well characterized, and most clinicians treat this as an exclusion until more data exists